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Takayasu's arteritis

**{{{Name|Takayasu's arteritis}}}**
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ICD-10	{{ICD10
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 ICD9           = 446.7|
 ICDO           = |
 Image          = |
 Caption        = |
 OMIM           = 207600 |
 MedlinePlus    = 001250 |
 eMedicineSubj  = radio |
 eMedicineTopic = 51 |
 DiseasesDB     = 12879 |

}} Takayasu's arteritis is an inflammatory diseaseof unknown etiologythat affects the aortaand its branches. Although it has been reported worldwide, it shows a predilection for young Asianwomen. Femaleswith this disease outnumber malesby 8:1, and the age of onset is typically between 15 and 30 yr. In the Western world, atherosclerosisis a more frequent cause of obstruction of the aortic arch vessels than is Takayasu's arteritis.

Inhaltsverzeichnis

1 History
2 Symptoms
3 Treatments
4 External links

History

The first case of Takayasu?s arteritis was described in 1908by Dr. Mikito Takayasu at the Annual Meeting of the Japan Ophthalmology Society. Dr. Takayasu described a peculiar "wreathlike" appearance of blood vesselsin the back of the eye (retina). Two Japanesecolleagues at the same meeting reported similar eye findings in patients whose wrist pulseswere absent. It is now known that the blood vessel malformations that occur in the retina are a response (new blood vessel growth) to arterial narrowings in the neck, and that the absence of pulses noted in some patients occur because of narrowings of blood vessels to the arms. The eye findings described by Dr. Takayasu are rarely seen in patients from North America.

Symptoms

About half of all patients develop an initial systemic illness with symptomsof malaise, fever, night sweats, weight loss, arthralgia, and fatigue. There is often an anemiaand marked elevation of the ESR. This phase gradually subsides and is followed by a more chronicstage characterized by inflammatory and obliterative changes in the aorta and its branches. The other half of patients with Takayasu's arteritis present with only late vascular changes, without an antecedent systemic illness. In the late stage, weakness of the arterial walls may give rise to localized aneurysms.

Treatments

The great majority of patients with Takayasu?s arteritis respond to prednisone. The usual starting dose is approximately 1 milligram per kilogram of body weight per day (for most people, this is approximately 60 milligrams a day). Because of the significant side effectsof long-term high?dose prednisone use, the starting dose is tapered over several weeks to a dose that the physicianfeels is tolerable for the patient.

External links

Johns Hopkins Vasculitis Center Discusses Takayasu's Arteritis
Takayasu's Arteritis Foundation
Takayasu's Arteritis Association
Chorus00389
Who Named Itsynd/2722
GPnotebook-362086386

This article is licensed under the GNU Free Documentation License.
It uses material from the http://en.wikipedia.org/wiki/Takayasu%27s+arteritis Wikipedia article Takayasu's arteritis.

All text is available under the terms of the GNU Free Documentation License