Oxazolidinone

Oxazolidinones are a class of azoles, oxazolidineswith the carbon between the nitrogen and oxygen oxidized to a ketone, hence oxazolidin - one.

Some of the most important oxazolidinones are the last generation of antibiotics used against gram-positive pathogens, including superbugssuch as Staphylococcus aureus. Developed during the nineties when several bacterial strains were becoming resistant against such antibiotics as Vancomycin. These antibiotics are considered as a choice of last resort where every other antibiotic cure has failed. They are applied intravenously.

Image:AZD2563.pngThe first commercially available oxazolidinone antibiotic was Linezolid. In 2002 AstraZenecaintroduced the AZD2563 antibiotic. Results indicate that AZD2563 has excellent, targeted activity against all common gram-positive bacteria, regardless of resistance to other classes of antibiotics.

Oxazolidinones are find use as the industrially-important Evans' chiral auxillaryieswhich are used to install stereocentersin organic molecules.

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It uses material from the http://en.wikipedia.org/wiki/Oxazolidinone Wikipedia article Oxazolidinone.