[ICD 10 Search]

Back
[ICD 10 Search]

Hyperlipoproteinemia

**{{{Name|Hyperlipoproteinemia}}}**
[[Image:{{{Image}}}\|190px\|center\|]] {{{Caption\|}}}
ICD-10	E78
ICD-O:	{{{ICDO}}}
ICD-9	272.0-272.4
OMIM	}}}
MedlinePlus	}}}
eMedicine	}}}
DiseasesDB	}}}

Hyperlipoproteinemia is the presence of elevated levels of lipoproteinin the blood. Lipids(fatty molecules) are transported in a proteincapsule, and the density of the lipids and type of protein determines the fate of the particle and its influence on metabolism.

Although the terms hyperlipoproteinemia and hypercholesterolemiaare often used interchangeably, the former is more specific. The term "hyperchylomicronemia" is used for an excess of chylomicrons.

Hyperlipoproteinemias are classified according to the Fredrickson/WHO classification (Fredrickson et al 1967), which is based on the pattern of lipoproteins on electrophoresisor ultracentrifugation.

Inhaltsverzeichnis

1 Hyperlipoproteinemia type I
2 Hyperlipoproteinemia type II
3 Hyperlipoproteinemia type III
4 Hyperlipoproteinemia type IV
5 Hyperlipoproteinemia type V
6 Unclassified forms
7 References
8 External links
- 8.1 General
- 8.2 Type I
- 8.3 Type II
- 8.4 Type III
- 8.5 Type IV
- 8.6 Type V

Hyperlipoproteinemia type I

This very rare form (also known as "Buerger-Gruetz syndrome", "Primary hyperlipoproteinaemia", or "familial hyperchylomicronemia"), is due to high chylomicrons, the particles that transfer fatty acids from the digestive tractto the liver.

Hyperlipoproteinemia type II

Hyperlipoproteinemia Type II is hyperlipidemia(hypercholesterolemia) in the Fredrickson classification, which is determined by lipoproteinelectrophoresis.

Hyperlipoproteinemia type II is further classified into:

Type IIa (elevated LDLonly)
- Polygenic hypercholesterolaemia
- Familial hypercholesterolemia(FH)
Type IIb - combined hyperlipidemia(elevated LDLand VLDL, leading to high triglycerideslevels)
- Familial combined hyperlipoproteinemia
- Secondary combined hyperlipoproteinemia

Hyperlipoproteinemia type III

This form is due to high chylomicronsand IDL (intermediate density lipoprotein).

Hyperlipoproteinemia type IV

This form is due to high triglycerides. It is also known as "hyperglyceridemia" (or "pure hyperglyceridemia".

Hyperlipoproteinemia type V

This type is very similar to Type I, but with high VLDL.

Unclassified forms

Non-classified forms are extremely rare:

Hypo-alpha lipoproteinemia
Hypo-beta lipoproteinemia

References

Fredrickson DS, Levy RI, Lees RS. Fat transport in lipoproteins: an integrated approach to mechanisms and disorders. N Engl J Med1967;276:148-156. PMID 5334266.

External links

General

The Fredrickson papers (with photos from early lipoprotein research
GP notebook

Type I

OMIM
MeritCare

Type II

OMIM
Merck

Type III

GPNotebook
Yahoo
WebMD

Type IV

Yahoo
OMIM
WebMD

Type V

OMIM

Image:Star of life.gif

This medical signarticle is a stub. You can helpWikipedia by expanding it.

This article is licensed under the GNU Free Documentation License.
It uses material from the http://en.wikipedia.org/wiki/Hyperlipoproteinemia Wikipedia article Hyperlipoproteinemia.

All text is available under the terms of the GNU Free Documentation License