Food allergy

In medicine, food allergy is hypersensitivity to dietarysubstances, leading to various types of gastrointestinal complaints. It occurs mainly, but not exclusively, in children. It is a common type of allergy, and is usually treated with an exclusion diet.

Signs and symptoms

Patients present with skin symptoms, throat tightness, shortness of breath, lightheadedness and/or stomach symptoms. The symptoms usually develop within half an hour of ingesting the allergen.

Rarely, food allergy can lead to anaphylactic shock: hypotension(low blood pressure) and loss of consciousness. This is a medical emergency. Allergens commonly associated with this type of reaction are peanuts, nuts, milk, egg and seafoods. Latex products can induce similar reactions.

Food allergy is thought to develop more easily in patients with the atopic syndrome, a very common combination of diseases: allergic rhinitisand conjunctivitis, eczemaand asthma. The syndrome has a strong inherited component; a family history of these diseases can be indicative of the atopic syndrome.

Diagnosis

The best method for diagnosing food allergy is to be assessed by an allergist. The allergist will discuss the symptoms that occured after the food ingestion. If the allergist feels the reaction is in keeping with a real food allergy, he/she will perform allergy skin tests. These skin tests are performed by a method called skin prick testing. It is generally very safe and tolerated even by young children. The results are available within 15 minutes. Another option is to perform blood testing, called RAST testing, for the foods that are suspected as allergens.

Important differential diagnoses are:

• Lactose intolerance; this generally develops later in life but can present in young patients in severe cases. This is due to an enzyme deficiency (lactase) and not allergy. It occurs in many non-Western people.
• Coeliac disease; this is an autoimmune disorder triggered by a specific wheatprotein (gliadin).
• Irritable bowel syndrome(IBS); although many IBS cases might be due to food allergy, this is an important diagnosis in patients with diarrhea in whom no allergens can be identified.
• C1 esterase inhibitor deficiency(hereditary angioedema); this rare diseasegenerally causes attacks of angioedema, but can present solely with abdominal painand occasional diarrhea.

Pathophysiology

See also allergyfor a general discussion of the background of allergy

Generally, introduction of allergens through the digestive tract is thought to induce immune tolerance. In individuals who are predisposed to developing allergies (atopic syndrome), the immune system produces IgEantibodies against protein epitopeson non-pathogenic substances, including dietary components. The IgE molecules are coated onto mast cells, which inhabit the mucosal lining of the digestive tract.

Upon ingesting an allergen, the IgE reacts with its protein epitopes and release (degranulate) a number of chemicals (including histamine), which lead to oedemaof the intestinal wall, loss of fluid and altered motility. The product is diarrhea.

The eight most common food allergies in North America and Europe are to eggs, milk, peanuts, soy, fish, shellfish, tree nuts, and wheat. Any food allergy has the potential to cause a fatal reaction.

Treatment

The mainstay of treatment for food allergy is avoidance of the foods that have been identified as allergens.

If the food is accidentally ingested and a systemic reaction occurs, then epinephrine (best delivered in an Epipen) should be used. It is possible that a second Epipen dose may be required for severe reactions. The patient should seek medical care.

At this time, there is no desensitization or allergy "shots" available for food allergy.

Statistics

For reasons that are not entirely understood, the diagnosis of food allergies has become more common in Western nations in recent times. (This trend seems to apply to asthma as well.) In the United States, it is believed that about 4% of the population suffers from food allergies. In children, this number is believed to be significantly higher.

The most common food allergens include peanuts, milk, eggs, tree nuts, fish, shellfish, soy, and wheat - these foods account for about 90% of all allergic reactions.

Differing views

Various medical specialties have a differing view on food allergies. What is called irritable bowel syndromeby many doctors (a stress-related functional disorder) is often interpreted by allergologiststo be food allergy.

In addition, many practitioners of complementary and alternative medicineascribe symptoms to food allergy where most classically trained doctors would not find a causal relationship. Examples are headaches, tiredness and hyperactivity. Nevertheless, hypoallergenicdiets can be of benefit in these conditions, indicating that the current medical views on food allergy may be too limited.

In children

Milkand soyallergies in children can often go undiagnosed for many months, causing much worry for parents and health risks for infants and children. Many infants with milk and soy allergies can show signs of colic, bloodin the stool, reflux, rashes and other harmful medical conditions. These conditions are often misdiagnosed as virusesor colic.

Many children who are allergic to cow's milk protein also show a cross sensitivity to soy-based products. There are infant formulas in which the milk and soy proteinsare degraded so when taken by an infant, their immune systemdoes not recognize the allergenand they can safely consume the product.

See also

• Allergy
• Soy allergy
• Medical emergency
• Anaphylaxis
• Oral Allergy Syndrome

External links

• The Food Allergy and Anaphylaxis Network
• Girl dies in peanut butter kiss
• Immune Tolerance Networkde:Nahrungsmittelallergie

ja:食物アレルギー nl:Voedselallergie en voedselintolerantie

This article is licensed under the GNU Free Documentation License.
It uses material from the http://en.wikipedia.org/wiki/Food+allergy Wikipedia article Food allergy.