Activated protein C resistance

Activated protein C resistance is a hemostatic disordercharacterized by a poor anticoagulantresponse to activated protein C(APC). This results in an increased risk of venous thrombosis.

Activated protein C (with protein S as a cofactor) degrades Factor Vaand Factor VIIIa. Activated protein C resistance is the inability of protein C to cleave factors V and/or VIII. This may be hereditary or acquired. The best known and most common hereditary form is Factor V Leiden. Acquired forms occur in the presence of elevated Factor VIII concentrations.

In most cases, APC resistance is associated with a single missense mutation in the gene for coagulation factor V (FV (Leiden)). It has been estimated that up to 64% of patients with venous thromboembolism might have activated protein C resistance.

References

• {{qif

  |test={{{Authorlink|}}}
  |then={{wikilink
        |1={{{Authorlink}}}
        |2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
        }}
  |else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}

}}{{qif

 |test={{{Coauthors|}}}
 |then=, {{{Coauthors}}}

}}{{qif

 |test={{{Date|}}}
 |then= ({{{Date}}})
 |else={{qif
   |test={{{Year|}}}
   |then={{qif
     |test={{{Month|}}}
     |then= ({{{Month}}} 2003)
     |else= (2003)
    }}
  }}

}}{{qif

 |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
 |then=. 

}}{{qif

 |test={{{URL|}}}
 |then=[{{{URL}}}
 |else=

}} Congenital and acquired activated protein C resistance{{qif

 |test={{{URL|}}}
 |then=]
 |else=

}}{{qif

 |test={{{Journal|}}}
 |then=. Semin Vasc Med

}}{{qif

 |test={{{Volume|}}}
 |then= 3

}}{{qif

 |test={{{Issue|}}}
 |then= (1)

}}{{qif

 |test={{{Pages|}}}
 |then=: 33-46

}}{{qif

 |test={{{ID|}}}
 |then=. {{{ID}}}

}}. PMID 15199491

• {{qif

  |test={{{Authorlink|}}}
  |then={{wikilink
        |1={{{Authorlink}}}
        |2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
        }}
  |else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}

}}{{qif

 |test={{{Coauthors|}}}
 |then=, {{{Coauthors}}}

}}{{qif

 |test={{{Date|}}}
 |then= ({{{Date}}})
 |else={{qif
   |test={{{Year|}}}
   |then={{qif
     |test={{{Month|}}}
     |then= ({{{Month}}} 2003)
     |else= (2003)
    }}
  }}

}}{{qif

 |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
 |then=. 

}}{{qif

 |test={{{URL|}}}
 |then=[{{{URL}}}
 |else=

}} The discovery of activated protein C resistance{{qif

 |test={{{URL|}}}
 |then=]
 |else=

}}{{qif

 |test={{{Journal|}}}
 |then=. J Thromb Haemost

}}{{qif

 |test={{{Volume|}}}
 |then= 1

}}{{qif

 |test={{{Issue|}}}
 |then= (1)

}}{{qif

 |test={{{Pages|}}}
 |then=: 3-9

}}{{qif

 |test={{{ID|}}}
 |then=. {{{ID}}}

}}. PMID 12871530

• {{qif

  |test={{{Authorlink|}}}
  |then={{wikilink
        |1={{{Authorlink}}}
        |2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
        }}
  |else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}

}}{{qif

 |test={{{Coauthors|}}}
 |then=, {{{Coauthors}}}

}}{{qif

 |test={{{Date|}}}
 |then= ({{{Date}}})
 |else={{qif
   |test={{{Year|}}}
   |then={{qif
     |test={{{Month|}}}
     |then= ({{{Month}}} 2000)
     |else= (2000)
    }}
  }}

}}{{qif

 |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
 |then=. 

}}{{qif

 |test={{{URL|}}}
 |then=[{{{URL}}}
 |else=

}} Activated protein C resistance: the most common risk factor for venous thromboembolism{{qif

 |test={{{URL|}}}
 |then=]
 |else=

}}{{qif

 |test={{{Journal|}}}
 |then=. J Am Board Fam Pract

}}{{qif

 |test={{{Volume|}}}
 |then= 13

}}{{qif

 |test={{{Issue|}}}
 |then= (2)

}}{{qif

 |test={{{Pages|}}}
 |then=: 111-5

}}{{qif

 |test={{{ID|}}}
 |then=. {{{ID}}}

}}. PMID 10764192

External links

• OMIM188055

This article is licensed under the GNU Free Documentation License.
It uses material from the http://en.wikipedia.org/wiki/Activated+protein+C+resistance Wikipedia article Activated protein C resistance.