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Microangiopathic hemolytic anemia

**{{{Name|Microangiopathic hemolytic anemia}}}**
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In medicine(hematology) microangiopathic hemolytic anemia (MAHA) is a subgroup of hemolytic anemia(anemia, loss of red blood cells through destruction) caused by factors in the small blood vessels. It is identified by the finding of anemia and schistocytes("bite cells") on microscopyof the blood film.

Automated analysers(the machines that perform routine full blood countsin most hospitals) are generally programmed to flag blood films that display red blood cell fragments or schistocytes.

The most important causes are:

Thrombotic thrombocytopenic purpura(TTP)
Hemolytic uremic syndrome(HUS)
Disseminated intravascular coagulation(DIC)
HELLP syndromeand eclampsia
Heparin-induced thrombocytopenia(HIT)
Severe glomerulonephritis
Several other rare causes

In all causes, the mechanism of MAHA is the formation of a fibrinmesh due to increased activity of the system of coagulation. The red blood cells are physically cut by these protein networks, and the fragments are identical to the schistocytes seen on light microscopy.

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