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Myelofibrosis

{{{Name|Myelofibrosis}}}
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ICD-10 (ICD-O9932, 9961)
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Myelofibrosis, one of the myeloproliferative diseases, is the gradual replacement of the bone marrowby connective tissue.

The replacement of the bone marrow tissue reduces the patient's ability to generate new blood cells resulting in chronic anemia. A prime feature is "extramedullary hematopoeisis", i.e. the remaining blood-forming cells migrate to other sites in the body, e.g. the liveror spleen. Patients will typically have an enlarged spleen and liver, (hepatosplenomegaly), and examination of the blood cells will show "teardrop cells".

Typically affecting patients more than 50 years old, it is a chronic and debilitating condition. Currently the only known cure is a bone marrow transplant. However the disease moves very slowly and patients can live for more than five or ten and even as long as eighteen more years after diagnososis, (with treatment). Since the bone marrow replacement treatment is very rigorous, painful and high risk, involving the use of chemotherapy to destroy the patients existing marrow tissue, and the typical patient is older, the bone marrow treatment is often not used.

There are other treatments available to reduce the affects of the disease that are repeated at regular intervals to maintain quality of life for the patient.

Further Reading

For more information, see:

  • Myeloproliferative Disease Support List
  • Association of Cancer Online Resource (ACOR) Myeloproliferative Disorders page
Image:Star of life2.pngThis medicalarticle is a stub. You can helpWikipedia by expanding it.
Health science- Medicine- Hematology
Hematological malignancyand White blood cells
Lymphoid: Lymphocytic leukemia(ALL, CLL) | Lymphoma(Hodgkin's disease, NHL) | LPD| Myeloma(Multiple myeloma, Extramedullary plasmacytoma)
Myeloid: Myelogenous leukemia(AML, CML) | MPD(Essential thrombocytosis, Polycythemia) | MDS| Myelofibrosis | Neutropenia
Red blood cells
Anemia| Hemochromatosis| Sickle-cell disease| Thalassemia| Hemolysis| Aplastic anemia| G6PD| Hereditary spherocytosis| Hereditary elliptocytosis| other hemoglobinopathies
Coagulationand Platelets
Thrombosis| Deep vein thrombosis| Pulmonary embolism| Hemophilia| ITP| TTP| DIC
Retrieved from "http://en.wikipedia.org/Myelofibrosis"



This article is licensed under the GNU Free Documentation License.
It uses material from the http://en.wikipedia.org/wiki/Myelofibrosis Wikipedia article Myelofibrosis.

 
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