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Myeloproliferative disease
The myeloproliferative diseases ("MPD"s) are a group of diseases of the bone marrowwhere excess cells are produced. They are related to, and may evolve into, myelodysplastic syndromeand acute myeloid leukemia, although the myeloproliferative diseases on the whole have a much better prognosis than these conditions. The concept of myeloproliferative disease was first proposed in 1951 by the eminent hematologist William Dameshek.
Although not a malignant neoplasm, MPDs are classified within the hematological neoplasms.
The myeloproliferative diseases are (with ICD-Ocodes provided):
- (9863/3) Chronic myelogenous leukemia(CML)
- (9950/3) Polycythemia vera(PCV)
- (9962/3) Essential thrombocytosis(ET)
- (9932/3, 9961/1) Myelofibrosis(increased connective tissue with decreased room for production of normal blood cells).
All MPDs arise from precursors of the "myeloid" lineage in the bone marrow. The lymphoid lineage may produce similar diseases, the lymphoproliferative disorders(acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemiaand multiple myeloma).
Reference
- Dameshek W. Some speculation on the myeloproliferative syndromes. Blood 1951;6:378-380. PMID 14820991.
Further Reading
For more information, see:
- Myeloproliferative Disease Support List
- Association of Cancer Online Resource (ACOR) Myeloproliferative Disorders page
| Health science- Medicine- Hematology
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| Hematological malignancyand White blood cells
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| Lymphoid: Lymphocytic leukemia(ALL, CLL) | Lymphoma(Hodgkin's disease, NHL) | LPD| Myeloma(Multiple myeloma, Extramedullary plasmacytoma)
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| Myeloid: Myelogenous leukemia(AML, CML) | MPD (Essential thrombocytosis, Polycythemia) | MDS| Myelofibrosis| Neutropenia
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| Red blood cells
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| Anemia| Hemochromatosis| Sickle-cell disease| Thalassemia| Hemolysis| Aplastic anemia| G6PD| Hereditary spherocytosis| Hereditary elliptocytosis| other hemoglobinopathies
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| Coagulationand Platelets
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| Thrombosis| Deep vein thrombosis| Pulmonary embolism| Hemophilia| ITP| TTP| DIC
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This article is licensed under the GNU Free Documentation License.
It uses material from the http://en.wikipedia.org/wiki/Myeloproliferative+disease Wikipedia article Myeloproliferative disease.
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