5T4

5T4 is an antigenexpressed in a number of carcinomas(oncofetal antigen or oncofetal trophoblastglycoprotein). It is a N-glycosylated transmembrane 72 kDa leucine-rich repeat glycoprotein.

5T4 is found in tumoursincluding the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. It has very limited expression in normal tissue but is widespread in malignant tumours throughout their development.

Its confined expression appears to give 5T4 the potential to be useful in cancerimmunotherapy. There has been extensive research into its role in antibody-directed immunotherapy through the use of the high-affinity murinemonoclonal antibody, mAb5T4, to deliver response modifiers (such as staphylococcus aureussuperantigen) accurately to a tumour.

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It uses material from the http://en.wikipedia.org/wiki/5T4 Wikipedia article 5T4.