List of human clusters of differentiation

This list includes Cluster of Differentiationor CD molecules.

• CD1= an MHC-like molecule that presents lipid molecules
• CD2= a type I transmembrane protein found on thymocytes, T cells, and some natural killer cells that acts as a ligand for CD58 and CD59 and is involved in signal transduction and cell adhesion; expressed in T-cell acute lymphoblastic leukemia and T-cell lymphoma.
• CD3= the signaling component of the T cell receptor(TCR) complex
• CD4= a co-receptor for MHCII; also a receptor used by HIV to enter T cells
• CD5= a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma.
• CD7= a type I transmembrane protein found on thymocytes, some T cells, monocytes, natural killer cells, and hemopoietic stem cells; expressed in patients with mycosis fungoides, some patients with T-cell acute lymphoblastic lymphoma, and a few patients with acute nonlymphocytic lymphoma.
• CD8= a co-receptor for MHCI; also found on a subset of myeloid dendritic cells.
• CD10= a type II transmembrane protein found on pre-B cells, germinal-center B cells, some neutrophils, kidney cells, T-cell precursors, and epithelial cells that acts as a zinc metalloprotease cleaving peptide bonds on the amino side of hydrophobic amino acids; expressed in acute lymphocytic leukemia and follicular-center-cell lymphomas.
• CD11c= a type I transmembrane protein found on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
• CD14= a membrane protein found on macrophageswhich binds to bacterial lipopolysaccharide.
• CD15= a phosphatidylinositol-anchored transmembrane protein found on neutrophils and which may be involved in phagocytosis; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias.
• CD19 = B-lymphocyte surface antigen B4
• CD20= a type III transmembrane protein found on B cells that forms a calcium channel in the cell wall allowing for the influx of calcium required for cell activation; expressed in B-cell lymphomas, hairy cell leukemia, and B-cell chronic lymphocytic leukemia.
• CD21= a type I transmembrane protein found on B cells, follicular dendritic cells, pharyngeal and cervical epithelial cells, some thymocytes, and some T cells that plays a role in signal transduction; expressed in hairy cell leukemia, B-cell lymphoma, and some T-cell acute lymphocytic leukemias.
• CD21= a type I transmembrane protein found in the cytoplasm of pre-B cells and on the surface of mature B cells that facilitates signal transduction; expressed in patients with hairy cell leukemias and in some with B-cell lymphomas.
• CD23= a type II transmembrane protein found on mature B cells, monocytes, activated macrophages, eosinophils, platelets, and dendritic cells that enhances capture and processing of antigen complexed with IgE.
• CD25= a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, and neuroblastomas.
• CD28= present on all T-cells, and when matched with the appropriate ligand, labeled B7 which can be either CD80 or CD86, it has costimulatory effecton the T-cell
• CD30= a type I transmembrane protein present on activated T and B cells that may play a role in cell activation and/or differentiation; expressed in Hodgkin disease, some T-cell lymphomas, and anaplastic large cell lymphomas.
• CD31= PECAM-1, a cell adhesion moleculeon plateletsand endothelialcells
• CD34= stem cellmarker, adhesion, found on hematopoieticprecursors (found in high concentrations in umbilical cord blood), capillaryendothelium, and embryonicfibroblasts
• CD35= Complement receptor 1(C3b/C4b receptor)
• CD36= Platelet glycoprotein IV or IIIb (GP IV / GP IIIb)
• CD38= involved in ecto-ADP-ribosyl cyclaseand cell activation on many hematopoietic, plasma, and B& T activated cells; marker increases with HIV seroconversion, coexpression with CD8 associated with progression (indicates persistent viral stimulation)
• CD45= a type I transmembrane protein present on all hemopoietic cells except erythrocytes that assists in cell activation; expressed in lymphomas, B-cell chronic lymphocytic leukemia, hairy cell leukemia, and acute nonlymphocytic leukemia.
• CD55= Complement Decay-Accelerating Factor (DAF): regulatory factor in one of the three pathways of the immune system complement cascade
• CD56= NCAM(neural cell adhesion molecule), a marker for natural killer cellsand some T-lymphocytes
• CD58= a membrane protein present on many hemopoietic cells and fibroblasts that acts as a ligand for CD2 and may be involved in T-cell function.
• CD59= Membrane attack complex inhibition factor (MACIF); MAC-inhibitory protein (MAC-IP); Antigen MEM43; Protectin: Immune system complement cascade regulatory factor
• CD71= Transferrinreceptor, mediates cellular uptake of iron
• CD80= when binded to CD28 on T-cells, can provide the costimulatory effect; also referred to as B7.1, one of the B7molecules.
• CD86= when binded to CD28 on T-cells, can provide the costimulatory effect; also referred to as B7.2, one of the B7molecules.
• CD89= FcalphaRI - receptor for IgA
• CD103= a type I transmembrane protein present on intestinal intraepithelial lymphocytes, some circulating leukocytes, and some T cells that facilitates adhesion to epithelia; expressed in hairy cell leukemia and some B-cell chronic lymphocytic leukemias.
• CD117= c-kit, the receptorfor Stem Cell Factor, a glycoproteinthat regulates cellular differentiation, particularly in hematopoiesis
• CD120= a receptor for Tumour Necrosis Factor, an inflammatory cytokine
• CD138= a plasma cell-surface glycoprotein, known as syndecan-1. Syndecan functions as the alpha receptor for collagen, fibronectin and thrombospondin.
• CD142= Tissue factor, a major initiator of blood-clotting
• CD143= Angiotensin-converting enzyme
• CD144= VE-Cadherin, a calcium-dependent adhesion molecule at intercellular junctions, found mainly in the vascular endothelium. Recent research indicates that CD144 may be present on some leucocytesas well.
• CDw186= CXCR6, a G-protein-coupled receptorfor the neutrophil-attacting chemokineCXCL6
• CD202a= Tie2, the receptor for angiopoietins, a family of angiogenicfactors
• CD235a= Glycophorin, a proteinon bloodcells

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