| Homepage | Imprint |
|
||
 |
BRCA1
{{Protbox codes |Symbol=BRCA1 |AltSymbols= |Chromosome=17 |Locus=q21-q24 |AApre=1863 |AApro=--- |HGNCid=BRCA1 |Codes=EntrezGene672, RefSeqNM_007295, UniProtP38398, OMIM113705 }} </table> Image:BRCA Genes-location of BRCA1 and BRCA2 on chromosomes 13 and 17.gif BRCA1 (breast cancer 1, early onset) is a humangenethat belongs to a class of genes known as tumor suppressor genes. Like many other tumor suppressor genes, BRCA1 regulates the cycle of cell division by keeping cells from growing and dividing too rapidly or in an uncontrolled way. In particular, it inhibits the growth of cells that line the milk ductsin the breast. The protein made by the BRCA1 gene is directly involved in the repair of damaged DNA. In the nucleus of many types of normal cells, the BRCA1 protein interacts with the protein produced by the RAD51gene to mend breaks in DNA. These breaks can be caused by natural radiation or other exposures, but also occur when chromosomes exchange genetic material in preparation for cell division. The BRCA2protein, which has a function similar to that of BRCA1, also interacts with the RAD51 protein. By repairing DNA, these three proteins play a role in maintaining the stability of the human genome. Research suggests that both the BRCA1 and BRCA2 proteins regulate the activity of other genes and play a critical role in embryo development. The BRCA1 protein probably interacts with many other proteins, including tumor suppressors and regulators of the cell division cycle. The BRCA1 gene is located on the long (q) arm of chromosome 17at position 21, from base pair38,449,843 to base pair 38,530,933.
Related conditionsCertain variations of the BRCA1 gene lead to an increased risk for breast cancer. Researchers have identified more than 600 mutationsin the BRCA1 gene, many of which are associated with an increased risk of cancer. These mutations can be changes in one or a small number of DNA base pairs(the building blocks of DNA). In some cases, large segments of DNA are rearranged. A mutated BRCA1 gene usually makes a proteinthat does not function properly because it is abnormally short. Researchers believe that the defective BRCA1 protein is unable to help fix mutations that occur in other genes. These defects accumulate and may allow cells to grow and divide uncontrollably to form a tumor. In addition to breast cancer, mutations in the BRCA1 gene also increase the risk of ovarian, prostateand colon cancers. See also
References
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2003)
|else= (2003)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. Am J Hum Genet
}}{{qif |test={{{Volume|}}}
|then= 72
}}{{qif |test={{{Issue|}}}
|then= (5)
}}{{qif |test={{{Pages|}}}
|then=: 1117-30
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 12677558
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2004)
|else= (2004)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} Recent developments in ovarian cancer genetics{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. Curr Opin Obstet Gynecol
}}{{qif |test={{{Volume|}}}
|then= 16
}}{{qif |test={{{Issue|}}}
|then= (1)
}}{{qif |test={{{Pages|}}}
|then=: 79-85
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 15128012
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2002)
|else= (2002)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} Highlight: BRCA1 and BRCA2 proteins in breast cancer{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. Microsc Res Tech
}}{{qif |test={{{Volume|}}}
|then= 59
}}{{qif |test={{{Issue|}}}
|then= (1)
}}{{qif |test={{{Pages|}}}
|then=: 68-83
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 12242698
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2004)
|else= (2004)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. Br J Cancer
}}{{qif |test={{{Volume|}}}
|then= 90
}}{{qif |test={{{Issue|}}}
|then= (10)
}}{{qif |test={{{Pages|}}}
|then=: 1995-2001
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 15138484
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2004)
|else= (2004)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. Clin Cancer Res
}}{{qif |test={{{Volume|}}}
|then= 10
}}{{qif |test={{{Issue|}}}
|then= (6)
}}{{qif |test={{{Pages|}}}
|then=: 2029-34
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 15041722
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2004)
|else= (2004)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} Cancer risks for male carriers of germline mutations in BRCA1 or BRCA2: a review of the literature{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. J Clin Oncol
}}{{qif |test={{{Volume|}}}
|then= 22
}}{{qif |test={{{Issue|}}}
|then= (4)
}}{{qif |test={{{Pages|}}}
|then=: 735-42
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 14966099
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2004)
|else= (2004)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. J Clin Oncol
}}{{qif |test={{{Volume|}}}
|then= 22
}}{{qif |test={{{Issue|}}}
|then= (12)
}}{{qif |test={{{Pages|}}}
|then=: 2328-35
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 15197194
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2003)
|else= (2003)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. Oncogene
}}{{qif |test={{{Volume|}}}
|then= 22
}}{{qif |test={{{Issue|}}}
|then= (37)
}}{{qif |test={{{Pages|}}}
|then=: 5784-91
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 12947386
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2002)
|else= (2002)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} BRCA1 and BRCA2 in hereditary breast cancer{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. Biochimie
}}{{qif |test={{{Volume|}}}
|then= 84
}}{{qif |test={{{Issue|}}}
|then= (1)
}}{{qif |test={{{Pages|}}}
|then=: 95-102
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 11900881
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2002)
|else= (2002)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} The relationship between the roles of BRCA genes in DNA repair and cancer predisposition{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. Trends Mol Med
}}{{qif |test={{{Volume|}}}
|then= 8
}}{{qif |test={{{Issue|}}}
|then= (12)
}}{{qif |test={{{Pages|}}}
|then=: 571-6
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 12470990
|test={{{Authorlink|}}}
|then={{wikilink
|1={{{Authorlink}}}
|2={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}
|else={{{Author|{{{Last|}}}{{{else{{{test|}}}|{{{test{{{test|}}}|{{{then|}}}}}}}}}}|then=, {{{First}}}}}}}}
}}{{qif |test={{{Coauthors|}}}
|then=, {{{Coauthors}}}
}}{{qif |test={{{Date|}}}
|then= ({{{Date}}})
|else={{qif
|test={{{Year|}}}
|then={{qif
|test={{{Month|}}}
|then= ({{{Month}}} 2002)
|else= (2002)
}}
}}
}}{{qif |test={{{Author|{{{Last|{{{Year|}}}}}}}}}
|then=.
}}{{qif |test={{{URL|}}}
|then=[{{{URL}}}
|else=
}} Cancer susceptibility and the functions of BRCA1 and BRCA2{{qif |test={{{URL|}}}
|then=]
|else=
}}{{qif |test={{{Journal|}}}
|then=. Cell
}}{{qif |test={{{Volume|}}}
|then= 108
}}{{qif |test={{{Issue|}}}
|then= (2)
}}{{qif |test={{{Pages|}}}
|then=: 171-82
}}{{qif |test={{{ID|}}}
|then=. {{{ID}}}
}}. PMID 11832208 External links
Categories: Oncology| Tumor supressor genes
| ||||
