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Burkitt's lymphoma

**{{{Name|Burkitt's lymphoma}}}**
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ICD-10	C83.7 (ICD-O9687/3)
ICD-O:	{{{ICDO}}}
ICD-9	200.2
OMIM	}}}
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Burkitt's lymphoma (or "Burkitt's tumor", or "Malignant lymphoma, Burkitt's type") is a type of cancerthat is associated with the Epstein-Barr virus, also the cause of mononucleosisas well as other cancers. It is named after Denis Parsons Burkitt, a surgeonwho first described the disease in 1956while working in equatorial Africa.

Children affected with the disease often also had chronic malariawhich is believed to have reduced resistance to the virus. This is known as classical African or endemic Burkitt's lymphoma.

Outside of central Africa, a type of non-Hodgkin's lymphomais found where cancer cells have a similar appearance to the cancer cells of classical African or endemic Burkitt's lymphoma. This condition is known as the non-African or sporadic type of Burkitt's lymphoma. Again it is believed that impaired immunity provides an opening for development of the Epstein-Barr virus. The translocation of the mycgene is seen in this lymphoma. (t: 8;14)

Microscopy

Burkitt's lymphoma demonstrates a starry sky appearance due to the macrophage ingestion of tumor cells.

Treatment

Chemotherapy
- cyclophosphamide
- doxorubicin
- vincristine
- methotrexate
- cytarabine
- ifosfamide
- etoposide

External link

General information

Image:Star of life2.png

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