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Planar patch clamp

A planar patch clamp is a novel device developed for high throughput electrophysiology.

Instead of moving the glass capillary to cell adhered to a substrate - cell suspension is pipetted on a chip containing a microstructured aperture. A single cell is then positioned on the hole by suction and a tight connection (Gigaseal) is formed. The planar geometry offers a variety of advantages compared to the classical experiment: - it allows for integration of microfluidics, which enables automatic compound application for ion channelscreening. - the system is accessible for *opticalor scanning probe techniques - *perfusion of the intracellular side can be performed. One example for an automated planar patch clampsystem is the Port-a-Patch.

External links

Device description Patch Clamp on a Chip Port-a-Patch ion channels

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It uses material from the http://en.wikipedia.org/wiki/Planar+patch+clamp Wikipedia article Planar patch clamp.

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