Amatoxin

Amatoxins are a subgrup of toxinsfound in Amanita phalloides and also in Galerina and Lepiota mushroom species.

Their swift intestinal absorption corroborated with their thermostabilityexplains why their toxic effects occur in a relative short period of time. The most severe effects are toxic hepatitiswith centrolobular necrosis and hepatic steatosis, as well as acute tubulointerstitial nephropathy, which altogether induce a severe hepatorenal syndrome(with a potential fatal outcome). The lethal dose is 0,1 mg/kg or 7 mg of toxin in adults, a dosage that can be found in 50g of mushrooms. There are 8 amatoxins of which the most active is alfa-amatoxin.fi:Amatoksiini

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