Gleason score

Image:Gleasonscore2.jpg A Gleason score is given to prostate cancerbased upon its microscopicappearance. The Gleason score is important because higher Gleason scores are associated with worse prognosis. This is because higher Gleason scores are given to cancer which is more aggressive. To assign a Gleason score, a piece of prostatic tissuemust be obtained (a biopsy). This is done either by removing the gland (prostatectomy) or by sampling the glandwith a needleintroduced through the rectum.

The Gleason score ranges from two to ten. A Gleason score of two is associated with the best prognosis and a score of ten with the worst. The final score is a combination of two different scores which each range from one to five. Gleason scores are associated with the following features:

• Grade 1 - The cancerous prostate closely resembles normal prostate tissue. The glands are small, well-formed, and closely packed
• Grade 2 - The tissue still has well-formed glands, but they are larger and have more tissue between them.
• Grade 3 - The tissue still has recognizable glands, but the cellsare darker. At high magnification, some of these cells have left the cells and are beginning to invade the surrounding tissue.
• Grade 4 - The tissue has few recognizable glands. Many cells are invading the surrounding tissue
• Grade 5 - The tissue does not have recognizable glands. There are often just sheets of cells throughout the surrounding tissue.

A pathologistexamines the biopsy specimen and attempts to give a score to the two most prominent patterns. These scores are then added to obtain the final Gleason score. For example, a prostate biopsy specimen may exhibit two different patterns, one which is assigned a number two and the other a number three. The final Gleason score in this case would be five.

The Gleason score is used to help evaluate the prognosis of men with prostate cancer. Together with other parameters, the Gleason score is incorporated into a strategy of prostate cancer stagingwhich predicts prognosis and helps guide therapy.

References

Gleason DF. The Veteran's Administration Cooperative Urologic Research Group: histologic grading and clinical staging of prostatic carcinoma. In Tannenbaum M (ed.) Urologic Pathology: The Prostate. Lea and Febiger, Philadelphia, 1977; 171-198.

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It uses material from the http://en.wikipedia.org/wiki/Gleason+score Wikipedia article Gleason score.